Fri Feb 02 2024

33 articles - From Friday Jan 26 2024 to Friday Feb 02 2024

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Guidelines

Guidelines and related publications, position statements, white papers, technical reviews, consensus statements, etc…


Meta-analysis

meta-analyses and systematic reviews

Inflamm Bowel Dis

Risk of Common Neurological Disorders in Adult Patients with Inflammatory Bowel Disease: A Systematic Review and Meta-analysis.

Inflammatory bowel disease may be modestly associated with increased risks of stroke, all-cause dementia, and PD. Further longitudinal studies are warranted to investigate potential links with MS, seizure/epilepsy, and peripheral neuropathy, as well as their clinical significance.

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Original articles

RCT, clinical trials, retrospective studies, etc…

Am J Clin Nutr

Adaptation of nutritional risk screening tools may better predict response to nutritional treatment. A secondary analysis of the randomized controlled trial EFFORT.

Adapting the NRS and MNA by including nutritional parameters only improved their ability to predict response to a nutrition intervention, but slightly reduces their overall prognostic performance. Scores dependent on disease severity may best be considered prognostic scores, while nutritional risk scores not including parameters reflecting disease severity may indeed improve a more personalized treatment approach for nourishment interventions. Clinical trial registration

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Dietary Patterns and Their Associations with Sociodemographic and Lifestyle Factors in Adult Survivors of Childhood Cancer: A Cross-Sectional Study.

Unhealthy dietary patterns are prevalent in adult survivors of childhood cancer, especially those with lower socioeconomic status and racial minorities. Interventions to improve diet and health in childhood cancer survivors need to concurrently address disparities that contribute to adherence to healthy dietary practices. Registration id ClinicalTrials.gov Identifier NCT00760656.

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Effect of cinnamon spice on continuously monitored glycemic response in adults with prediabetes: a 4-week randomized controlled crossover trial.

Cinnamon, a widely available and low-cost supplement, may contribute to better glucose control when added to the diet in people who have obesity-related prediabetes.

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Effect of lipid-based nutrient supplements on micronutrient status and hemoglobin among children with stunting: secondary analysis of a randomized, controlled trial in Uganda.

LNS supplementation increased Hb and improved iron, cobalamin and folate status, but not vitamin A status among children with stunting. LNS should be considered for children with stunting. ( ISRCTN13093195) CLINICAL TRIAL REGISTRY ISRCTN 13093195, website

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Metabolomics of Ramadan fasting and associated risk of chronic diseases.

Ramadan fasting is associated with short-term favorable changes in the metabolic profile concerning risk of some chronic diseases. These findings should be further investigated in future, larger studies of longer follow-up with clinical outcomes.

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Plant stanol consumption increases anti-COVID-19 antibody responses, independent of changes in serum cholesterol concentrations: a randomized controlled trial.

Consuming plant stanols (4g/day) affects immune responses to COVID-19 vaccinations, translating into increased serum anti-COVID-19 IgM concentrations in subjects with overweight/obesity. Only in IgG seroconverted subjects, serum anti-COVID-19 IgG concentrations also increased. These effects were independent of reductions in LDL cholesterol. These results suggest that this high-risk group for COVID-19 complications could benefit from plant stanol consumption. Clinical Trial Registry website and number clinicaltrials.gov, NCT04844346.

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Temporal gut microbiota variability and association with dietary patterns: from the one-year observational DCH-NG MAX study.

In the DCH-NG MAX, 39% of the genera had an ICC>0.5 over one year, suggesting that these genera could be studied with health outcomes in prospective analyses with acceptable precision. Adherence to the Nordic, Mediterranean, and plant-based diets differed between bacterial subgroups and was associated with higher abundance of genera with fiber-degrading properties. Fruits, vegetables, whole grains/cereals, and nuts were frequently associated with these genera.

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The associations of serum vitamin D status and vitamin D supplements use with all-cause dementia, Alzheimer's disease, and vascular dementia: a UK Biobank based prospective cohort study.

Regular users of vitamin D and multivitamins had 17% and 14% lower risk of AD (HR [95% CI]: 0.83 [0.71-0.98]) and VD (HR [95% CI]: 0.86 [0.75-0.98]) incidence, respectively. While our findings indicate potential benefits of vitamin D supplementation for dementia prevention, randomized controlled trials are essential for definitive evidence.

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Inflamm Bowel Dis

Breaking Down Barriers: Epithelial Contributors to Monogenic IBD Pathogenesis.

We illustrate how impairment of any of these categories can result in IBD. This work reviews the current understanding of the genes involved in maintaining the intestinal barrier, the inheritance patterns that result in dysfunction, features of IBD resulting from these disorders, and pertinent translational work in this field.

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Crohn's Disease-Associated Pathogenic Mutation in the Manganese Transporter ZIP8 Shifts the Ileal and Rectal Mucosal Microbiota Implicating Aberrant Bile Acid Metabolism.

In the search for genotype-specific therapeutic paradigms for patients with Crohn's disease, these data suggest targeting the FGF19 pathway in ZIP8 A391T carriers. Aberrant bile acid metabolism may precede development of Crohn's disease and prioritize study of the interactions between manganese homeostasis, bile acid metabolism and signaling, and complicated ileal Crohn's disease.

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Extended Induction and Prognostic Indicators of Response in Patients Treated with Mirikizumab with Moderately to Severely Active Ulcerative Colitis in the LUCENT Trials.

With "extended induction," total of 80.3% mirikizumab-treated patients achieved clinical response by W24. Potential prognostic factors determining response include disease severity, disease phenotype, C-reactive protein, and previous biologic therapy.

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Ion Transport Basis of Diarrhea, Paneth Cell Metaplasia, and Upregulation of Mechanosensory Pathway in Anti-CD40 Colitis Mice.

Our data demonstrate that the anti-CD40 colitis model shows key features of IBD observed in the human disease, hence making it a suitable model to investigate the pathophysiology of ulcerative colitis (UC).

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Unveiling Colitis: A Journey through the Dextran Sodium Sulfate-induced Model.

However, although DSS-induced colitis is the most popular and flexible model for preclinical IBD research, it is not an exact replica of human colitis, and some results obtained from this model cannot be directly applied to humans. This review aims to comprehensively discuss different factors that may be involved in the pathogenesis of DSS-induced colitis and the issues that should be considered when using this model for translational purposes.

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J Crohns Colitis

Intestinal epithelia and myeloid immune cells shape colitis severity and colorectal carcinogenesis via High-mobility group box protein 1.

Enterocytes and myeloid cells context-dependently regulate host responses to severe colitis and maladaptive intestinal wound healing via HMGB1.

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Liver Transpl

A retrospective cohort study of socioeconomic deprivation and post-liver transplant survival in adults.

In summary, liver transplant recipients experiencing high socioeconomic deprivation tended to have worse post-transplant survival. Further research is needed to elucidate the extent to which neighborhood socioeconomic deprivation contributes to mortality risk and identify effective measures to improve survival in more socioeconomically disadvantaged liver transplant recipients.

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Cannabis use in liver transplant candidates and recipients.

With over 75% of LT recipients transplanted in states with legalized use of medicinal and/or recreational cannabis, LT clinicians must have expertise in assessment of cannabis use given its potential impact on clinical care. In this review, we provide an understanding of nomenclature and tools to assess cannabis use, highlight essential components to guide clinical policy development and implementation, and discuss potential impacts of cannabis use on patients' transplant course.

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Reconstruction of all hepatic arteries in right lobe grafts with two hepatic arteries and zero percent hepatic artery thrombosis.

In our series, although the smaller HA in the two HA group should increase the risk of HAT, HAT did not occur in this group. Therefore, reconstructing both HAs when possible may be a reasonable approaches in LDLT using a right liver graft with two HA openings.

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Pancreas

Cell of Origin of Pancreatic cancer: Novel Findings and Current Understanding.

We acknowledge the value of precise markers and suitable tracing tools to discern the cell of origin, as it can facilitate the creation of more effective models for PDAC exploration. These conclusions shed light on our existing understanding of foundational genetically engineered mouse models and focus on the origin and development of PDAC.

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Efficacy and Toxicity of Palliative Chemotherapy in Elderly Patients With Advanced Pancreatic Cancer.

The efficacy and toxicity of chemotherapy in elderly patients with advanced PDAC were comparable with those in younger patients.

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Impact of Preoperative Diabetes Mellitus on Postoperative Outcomes in Elective Pancreatic Surgery and Its Implications for Prehabilitation Practice.

One-quarter of the patients scheduled for pancreatoduodenectomy had DM; over half of them had poor glycemic control. The association between DM status and surgical site infections revealed in this study emphasizes the importance of adequate preoperative glycemic control.

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The Role of Intraoperative Pancreatoscopy in the Surgical Management of Intraductal Papillary Mucinous Neoplasms: A Scoping Review.

The current literature suggests a potential role of integration of IOP into the management of patients with IPMNs. This tool is safe and feasible and can result in changes in surgical decision making.

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Pancreatology

Modeling health outcomes associated with BRCA testing and treatment strategies for patients with metastatic pancreatic cancer.

Patients with mPC achieved longest health outcomes (as measured by mean PF LYs, LYs and QALYs) with a scenario of early gBRCA testing and availability of olaparib maintenance. The results were primarily driven by improved health outcomes associated with higher efficacy of platinum-based chemotherapies and olaparib used in gBRCAm patients.

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Prevalence and risk factors of fatigue and its association with quality of life among patients with chronic pancreatitis: A cross-sectional study.

This study indicated that Fatigue is a common symptom and has a negative impact on the QoL of patients with CP. Steatorrhea, smoking history, endoscopic treatment, depression, and sleep disorders were associated with fatigue.

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The prognostic and predictive role of class III β-Tubulin and hENT1 expression in patients with advanced pancreatic ductal adenocarcinoma.

Our findings indicate that tumor TUBB3 and hENT1 expression may predict the efficacy of the GnP regimen, and low TUBB3 and high hENT1 expression (TUBB3 low /hENT1 high ) are associated with a higher DCR and longer PFS in patients treated with GnP. Evaluating TUBB3 and hENT1 jointly can identify the patients most (as well as least) likely to benefit from GnP chemotherapy.

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Reviews&Editorials

Plenty of the editorials are available as full text through the publisher website using the provided link

Am J Clin Nutr

PKU in Adults: What do we know?

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Inflamm Bowel Dis

Methodological Standards When Reporting From National Databases.

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Miscellaneous

misc publications eg case reports, tools of the trade, images of the month, etc…

Liver Transpl

"Not too much, not too little, just right"-Finding the Goldilocks point in pediatric immunosuppression minimization.

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Liver transplant activity for alcohol associated hepatitis after OPTN diagnosis updates.

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Protein induced by Vitamin-K Absence II: Another key to create a common language.

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Robotic surgery: Moving the needle in living donor hepatectomy.

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The BIG question: Can we stop the use of HBIG?

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Transplantation's next frontier: The promise of deceased donor studies.

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Letters&Replies

Letters to the editors and authors’ replies